Beyond Infection: The Realities of Primary Immunodeficiency. A CE | CME Supplement.


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Jointly provided by Partners for Advancing Clinical Education (PACE) and Ig National Society, Inc.

Original Release Date: February 2021
Last Review Date: February 2024
Expiration Date: February 2025

Lori Broderick, MD, PhD
Jennifer Leiding, MD
Paul J. Maglione, MD, PhD
Richard Wasserman, MD, PhD

Continuing Education: Nursing 2.0 contact hours | Pharmacy 2.0 contact hours |  Physician 2.0 AMA PRA Category 1 Credit(s)™

Target Audience
This activity is intended for physicians, nurses, pharmacists, and other healthcare professionals who care for patients in need of immunoglobulin therapy and specialty biologics.

Educational Objectives
Upon completion of this activity, participants should be able to:

Lesson 1: Secondary Immune Deficiences from Biological Agents

  • Review the nomenclature for monoclonal antibodies
  • Explain the mechanisms for prolonged hypogammaglobulinemia with Rituximab
  • Review the immune and infectious consequences of some of the most frequently used biologics on the immune system
  • Review the adverse effects of immune check point inhibitors

Lesson 2: Autoinflammatory Disorders

  • Define autoinflammatory disorders
  • Discuss the role of phenotyping and family history in the diagnosis of autoinflammatory disease
  • Describe the basis of inflammasome-mediated inflammation
  • Describe the role of cytokine-targeting biologics as therapy for these disorders

Lesson 3: Immune Dysregulation – A New Facet of Primary Immunodeficiency Disease (PIDD)

  • Discuss non-infectious presentations and manifestations of primary immunodeficiency
  • Formulate a differential diagnosis for children with suspected immunodeficiency
  • Identify new rare defects of the immune system that cause immunodeficiency

Lesson 4: Pulmonary complications of primary immunodeficiency

  • Explain key aspects of the pathogenesis and clinical presentation of pulmonary disease in primary immunodeficiency
  • Summarize our understanding of asthma and chronic obstructive pulmonary disease in primary immunodeficiency
  • Recognize the physiology, clinical presentation, and therapeutic approach to bronchiectasis in primary immunodeficiency
  • Identify distinct forms of interstitial lung disease occurring in primary immunodeficiency

Lesson 5: The Complex PI Patient: The Tangled Web of Immunodeficiency and Its Complications

  • Review the range of disorders of host defense
  • Identify the non-infectious co-morbidities associated with PI
  • Recognize that pediatric and adult PI patients are subject to distinct but overlapping clinical problems
  • Describe how the complexity in a PI patient derives from multiple, interacting problems