Beyond Infection: The Realities of Primary Immunodeficiency | Webinar Series


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Jointly provided by Partners for Advancing Clinical Education (PACE) and Ig National Society, Inc.

Original Release Date: February 2021
Last Review Date: December 2023
Expiration Date: December 2024

Ken Paris, MD, MPH
Lori Broderick, MD, PhD
Richard Wasserman, MD, PhD
PJ Magilone, MD, PhD
Jennifer Leiding, MD
Mark Ballow, MD

Continuing Education: Nursing 4.25 contact hour | Pharmacy 4.25 contact hour |  Physician 4.25 AMA PRA Category 1 Credit(s)™

Recertification: 4.25 IgCN® / IgCP® Recertification Units

Target Audience

This activity is intended for physicians, nurses, pharmacists, and other healthcare professionals who care for patients in need of immunoglobulin therapy and specialty biologics.

Educational Objectives
Upon completion of this activity, participants should be able to:

Part 1

  • Discuss the components of our immune system.
  • Describe a typical antibody deficiency syndrome that is treated with immunoglobulin.
  • Describe the impact of Ig replacement on the health of patients with PI.

Part 2

  • Define autoinflammatory disorders.
  • Discuss the role of phenotyping and family history in diagnosis.
  • Describe the basics of inflammasome mediated inflammation.
  • Describe the role of cytokine-targeting biologics as therapy for these disorders.

Part 3

  • Review the range of disorders of host defense.
  • Identify the non-infectious co-morbidities associated with PI.
  • Recognize that pediatric and adult PI patients are subject to distinct but overlapping clinical problems.
  • Explain how complexity in a PI patient derives from multiple, interacting problems.

Part 4

  • Explain key aspects of the pathogenesis and clinical presentation of pulmonary disease in primary immunodeficiency.
  • Summarize our understanding of asthma and chronic obstructive pulmonary disease in primary immunodeficiency.
  • Recognize the physiology, clinical presentation, and therapeutic approach to bronchiectasis in primary immunodeficiency.
  • Identify distinct forms of interstitial lung disease occurring in primary immunodeficiency.

Part 5

  • Discuss non-infectious presentations and manifestations of primary immunodeficiency.
  • Formulate a differential diagnosis for children with suspected immunodeficiency.
  • Identify new rare defects of the immune system that cause immunodeficiency.

Part 6

  • Review the nomenclature for monoclonal antibodies.
  • Explain the mechanisms for prolonged hypogammaglobulinemia with biologic therapy.
  • Review the immune and infectious consequences of some of the most frequently used biologics on the immune system.
  • Review the adverse effects of immune check point inhibitors.

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