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Secondary Immune Deficiencies From Biological Agents

Author:
Mark Ballow, MD
Professor of Pediatrics
Division of Allergy and Immunology
Morsani College of Medicine
University of South Florida St. Petersburg, Florida 

OBJECTIVES 

  1. Review the nomenclature for monoclonal antibodies 
  2. Understand the mechanisms for prolonged hypogammaglobulinemia with Rituximab 
  3. Review the immune and infectious consequences of some of the most frequently used biologics on the immune system 
  4. Review the adverse effects of immune checkpoint inhibitors